WFU

個人簡歷

2017年11月15日 星期三

個人簡歷

Daw-Yang Hwang, MD, PhD    黃道揚 醫師



FB:基因診斷 黃道揚醫師

Email : dawyanghwangkmu@gmail.com


現職 


國家衛生研究院 助研究員

高雄醫學大學附設中和紀念醫院腎臟內科特約主治醫師

高雄醫學大學醫學系助理教授 (合聘)


學歷 


高雄醫學大學醫學士

美國凱斯西儲大學生理與生物物理博士

美國密西根大學/霍華德休斯醫學研究所 博士後研究員

美國波士頓兒童醫院/哈佛醫學院/霍華德休斯醫學研究所 博士後研究員


發表文獻

1: Lee JJ, Ho MC, Huang CY, Wen CH, Cheng YC, Hsu YH, Hwang DY, Lu HE, Chen HC,
Hsieh PCH. Induced pluripotent stem cells derived from an autosomal dominant
polycystic kidney disease patient carrying a PKD1 Q533X mutation. Stem Cell Res.
2017 Oct 28;25:83-87. doi: 10.1016/j.scr.2017.10.026. [Epub ahead of print]
PubMed PMID: 29121521.

2: Ho MC, Huang CY, Lee JJ, Hsu SH, Cheng YC, Hsu YH, Hwang DY, Lu HE, Chen HC,
Hsieh PCH. Generation of an induced pluripotent stem cell line, IBMS-iPSC-014-05,
from a female autosomal dominant polycystic kidney disease patient carrying a
common mutation of R803X in PKD2. Stem Cell Res. 2017 Oct 10;25:38-41. doi:
10.1016/j.scr.2017.10.005. [Epub ahead of print] PubMed PMID: 29055226.

3: Huang CY, Ho MC, Lee JJ, Hwang DY, Ko HW, Cheng YC, Hsu YH, Lu HE, Chen HC,
Hsieh PCH. Generation of induced pluripotent stem cells derived from an autosomal
dominant polycystic kidney disease patient with a p.Ser1457fs mutation in PKD1.
Stem Cell Res. 2017 Oct;24:139-143. doi: 10.1016/j.scr.2017.09.004. Epub 2017 Sep
15. PubMed PMID: 29034881.

4: van der Ven AT, Shril S, Ityel H, Vivante A, Chen J, Hwang DY, Laricchia KM,
Lek M, Tasic V, Hildebrandt F. Whole-Exome Sequencing Reveals FAT4 Mutations in a
Clinically Unrecognizable Patient with Syndromic CAKUT: A Case Report. Mol
Syndromol. 2017 Aug;8(5):272-277. doi: 10.1159/000477750. Epub 2017 Jul 1. PubMed
PMID: 28878612; PubMed Central PMCID: PMC5582506.

5: Hung CC, Lin HY, Hwang DY, Kuo IC, Chiu YW, Lim LM, Hwang SJ, Chen HC.
Diabetic Retinopathy and Clinical Parameters Favoring the Presence of Diabetic
Nephropathy could Predict Renal Outcome in Patients with Diabetic Kidney Disease.
Sci Rep. 2017 Apr 21;7(1):1236. doi: 10.1038/s41598-017-01204-6. PubMed PMID:
28432319; PubMed Central PMCID: PMC5430840.

6: Chuang LL, Hwang DY, Tsai KB, Chan HM, Chiang FY, Hsiao PJ. A cohort study on
10-year survival of sporadic medullary thyroid carcinoma with somatic RET
mutation. Kaohsiung J Med Sci. 2016 Nov;32(11):545-551. doi:
10.1016/j.kjms.2016.08.012. Epub 2016 Oct 14. PubMed PMID: 27847096.

7: Lim LM, Tsai NC, Lin MY, Hwang DY, Lin HY, Lee JJ, Hwang SJ, Hung CC, Chen HC.
Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in
Chronic Kidney Disease Patients Treated with Diuretics. Sci Rep. 2016 Nov
14;6:36817. doi: 10.1038/srep36817. PubMed PMID: 27841359; PubMed Central PMCID:
PMC5108044.

8: Lin HC, Hwang DY, Lim KH. Targeted re-sequencing of TET2 in Taiwanese patients
with myelodysplastic/myeloproliferative neoplasms. Med Oncol. 2016 Aug;33(8):92.
doi: 10.1007/s12032-016-0808-y. Epub 2016 Jul 14. PubMed PMID: 27418193.

9: Vivante A, Hwang DY, Kohl S, Chen J, Shril S, Schulz J, van der Ven A, Daouk
G, Soliman NA, Kumar AS, Senguttuvan P, Kehinde EO, Tasic V, Hildebrandt F. Exome
Sequencing Discerns Syndromes in Patients from Consanguineous Families with
Congenital Anomalies of the Kidneys and Urinary Tract. J Am Soc Nephrol. 2017
Jan;28(1):69-75. doi: 10.1681/ASN.2015080962. Epub 2016 May 5. PubMed PMID:
27151922; PubMed Central PMCID: PMC5198271.

10: Kohl S, Chen J, Vivante A, Hwang DY, Shril S, Dworschak GC, Van Der Ven A,
Sanna-Cherchi S, Bauer SB, Lee RS, Soliman NA, Kehinde EO, Reutter HM, Tasic V,
Hildebrandt F. Targeted sequencing of 96 renal developmental microRNAs in 1213
individuals from 980 families with congenital anomalies of the kidney and urinary
tract. Nephrol Dial Transplant. 2016 Aug;31(8):1280-3. doi: 10.1093/ndt/gfv447.
Epub 2016 Jan 29. PubMed PMID: 26908769; PubMed Central PMCID: PMC4967727.

11: Kuo IC, Lin HY, Niu SW, Hwang DY, Lee JJ, Tsai JC, Hung CC, Hwang SJ, Chen
HC. Glycated Hemoglobin and Outcomes in Patients with Advanced Diabetic Chronic
Kidney Disease. Sci Rep. 2016 Jan 28;6:20028. doi: 10.1038/srep20028. PubMed
PMID: 26818011; PubMed Central PMCID: PMC4730215.

12: You-Hsien Lin H, Yen CY, Lim LM, Hwang DY, Tsai JC, Hwang SJ, Hung CC, Chen
HC. Microscopic Haematuria and Clinical Outcomes in Patients With Stage 3-5
Nondiabetic Chronic Kidney Disease. Sci Rep. 2015 Oct 16;5:15242. doi:
10.1038/srep15242. PubMed PMID: 26472621; PubMed Central PMCID: PMC4607953.

13: Lim LM, Zhao X, Chao MC, Chang JM, Chang WC, Kao HY, Hwang DY, Chen HC. Novel
Vitamin D Receptor Mutations in Hereditary Vitamin D Resistant Rickets in
Chinese. PLoS One. 2015 Sep 30;10(9):e0138152. doi: 10.1371/journal.pone.0138152.
eCollection 2015. PubMed PMID: 26422470; PubMed Central PMCID: PMC4589239.

14: Hilger AC, Halbritter J, Pennimpede T, van der Ven A, Sarma G, Braun DA,
Porath JD, Kohl S, Hwang DY, Dworschak GC, Hermann BG, Pavlova A, El-Maarri O,
Nöthen MM, Ludwig M, Reutter H, Hildebrandt F. Targeted Resequencing of 29
Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human
VATER/VACTERL Association. Hum Mutat. 2015 Dec;36(12):1150-4. doi:
10.1002/humu.22859. Epub 2015 Sep 14. PubMed PMID: 26294094; PubMed Central
PMCID: PMC4643331.

15: Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY,
Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi
S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH,
Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM,
Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A,
Hildebrandt F. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via
Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015 Aug
6;97(2):291-301. doi: 10.1016/j.ajhg.2015.07.001. Epub 2015 Jul 30. PubMed PMID:
26235987; PubMed Central PMCID: PMC4862256.

16: Hwang DY, Kohl S, Fan X, Vivante A, Chan S, Dworschak GC, Schulz J, van Eerde
AM, Hilger AC, Gee HY, Pennimpede T, Herrmann BG, van de Hoek G, Renkema KY,
Schell C, Huber TB, Reutter HM, Soliman NA, Stajic N, Bogdanovic R, Kehinde EO,
Lifton RP, Tasic V, Lu W, Hildebrandt F. Mutations of the SLIT2-ROBO2 pathway
genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and
urinary tract. Hum Genet. 2015 Aug;134(8):905-16. doi: 10.1007/s00439-015-1570-5.
Epub 2015 May 31. PubMed PMID: 26026792; PubMed Central PMCID: PMC4497857.

17: Lin HY, Hwang DY, Lee SC, Kuo HT, Kuo MC, Chang JM, Tsai JC, Hung CC, Hwang
SJ, Chen HC. Urinary neutrophil gelatinase-associated lipocalin and clinical
outcomes in chronic kidney disease patients. Clin Chem Lab Med. 2015
Jan;53(1):73-83. doi: 10.1515/cclm-2014-0647. PubMed PMID: 25153411.

18: Yen JH, Chang CM, Hsu YW, Lee CH, Wu MS, Hwang DY, Chen BK, Liao HT, Wu MT,
Chang WC. A polymorphism of ORAI1 rs7135617, is associated with susceptibility to
rheumatoid arthritis. Mediators Inflamm. 2014;2014:834831. doi:
10.1155/2014/834831. Epub 2014 Apr 8. PubMed PMID: 24808640; PubMed Central
PMCID: PMC3997980.

19: Hwang DY, Chien SC, Hsu YW, Kao CC, Cheng SY, Lu HC, Wu MS, Chang JM. Genetic
polymorphisms of ORAI1 and chronic kidney disease in Taiwanese population. Biomed
Res Int. 2014;2014:290863. doi: 10.1155/2014/290863. Epub 2014 Mar 17. PubMed
PMID: 24745010; PubMed Central PMCID: PMC3976823.

20: Kohl S, Hwang DY, Dworschak GC, Hilger AC, Saisawat P, Vivante A, Stajic N,
Bogdanovic R, Reutter HM, Kehinde EO, Tasic V, Hildebrandt F. Mild recessive
mutations in six Fraser syndrome-related genes cause isolated congenital
anomalies of the kidney and urinary tract. J Am Soc Nephrol. 2014
Sep;25(9):1917-22. doi: 10.1681/ASN.2013101103. Epub 2014 Apr 3. PubMed PMID:
24700879; PubMed Central PMCID: PMC4147986.

21: Wu YL, Hwang DY, Hsiao HP, Ting WH, Huang CY, Tsai WY, Chen HC, Chao MC, Lo
FS, Tsai JD, Yang S, Shih SL, Lin SP, Lin CL, Lee YJ. Mutations in
pseudohypoparathyroidism 1a and pseudopseudohypoparathyroidism in ethnic Chinese.
PLoS One. 2014 Mar 20;9(3):e90640. doi: 10.1371/journal.pone.0090640. eCollection
2014. PubMed PMID: 24651309; PubMed Central PMCID: PMC3961212.

22: Hwang DY, Dworschak GC, Kohl S, Saisawat P, Vivante A, Hilger AC, Reutter HM,
Soliman NA, Bogdanovic R, Kehinde EO, Tasic V, Hildebrandt F. Mutations in 12
known dominant disease-causing genes clarify many congenital anomalies of the
kidney and urinary tract. Kidney Int. 2014 Jun;85(6):1429-33. doi:
10.1038/ki.2013.508. Epub 2014 Jan 15. PubMed PMID: 24429398; PubMed Central
PMCID: PMC4040148.

23: Vivante A, Kohl S, Hwang DY, Dworschak GC, Hildebrandt F. Single-gene causes
of congenital anomalies of the kidney and urinary tract (CAKUT) in humans.
Pediatr Nephrol. 2014 Apr;29(4):695-704. doi: 10.1007/s00467-013-2684-4. Epub
2014 Jan 8. Review. PubMed PMID: 24398540; PubMed Central PMCID: PMC4676405.

24: Wang YK, Hwang DY, Wang SS, Hwang SJ, Chen LT, Kuo MC. Terlipressin-induced
hyponatremic encephalopathy in a noncirrhotic patient. Kaohsiung J Med Sci. 2013
Dec;29(12):691-4. doi: 10.1016/j.kjms.2013.08.003. Epub 2013 Sep 10. PubMed PMID:
24296059.

25: Saisawat P, Kohl S, Hilger AC, Hwang DY, Yung Gee H, Dworschak GC, Tasic V,
Pennimpede T, Natarajan S, Sperry E, Matassa DS, Stajić N, Bogdanovic R, de
Blaauw I, Marcelis CL, Wijers CH, Bartels E, Schmiedeke E, Schmidt D, Märzheuser
S, Grasshoff-Derr S, Holland-Cunz S, Ludwig M, Nöthen MM, Draaken M, Brosens E,
Heij H, Tibboel D, Herrmann BG, Solomon BD, de Klein A, van Rooij IA, Esposito F,
Reutter HM, Hildebrandt F. Whole-exome resequencing reveals recessive mutations
in TRAP1 in individuals with CAKUT and VACTERL association. Kidney Int. 2014
Jun;85(6):1310-7. doi: 10.1038/ki.2013.417. Epub 2013 Oct 23. PubMed PMID:
24152966; PubMed Central PMCID: PMC3997628.

26: Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N,
Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E,
Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA,
Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman
JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE,
Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F.
Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59
and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet. 2013
Oct 3;93(4):672-86. doi: 10.1016/j.ajhg.2013.08.015. PubMed PMID: 24094744;
PubMed Central PMCID: PMC3791264.

27: Lim LM, Chang JM, Wang IF, Chang WC, Hwang DY, Chen HC. Atypical X-linked
agammaglobulinaemia caused by a novel BTK mutation in a selective immunoglobulin
M deficiency patient. BMC Pediatr. 2013 Sep 27;13:150. doi:
10.1186/1471-2431-13-150. PubMed PMID: 24074005; PubMed Central PMCID:
PMC3849551.

28: Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R,
Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT,
Rosenfeld M, Diaz KA, Olbrich H, Wolf WE, Sheridan E, Batten TF, Halbritter J,
Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns KA, Ferkol TW, Sagel SD,
Olivier KN, Morgan LC, Werner C, Raidt J, Pennekamp P, Sun Z, Zhou W, Airik R,
Natarajan S, Allen SJ, Amirav I, Wieczorek D, Landwehr K, Nielsen K, Schwerk N,
Sertic J, Köhler G, Washburn J, Levy S, Fan S, Koerner-Rettberg C, Amselem S,
Williams DS, Mitchell BJ, Drummond IA, Otto EA, Omran H, Knowles MR, Hildebrandt
F. ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. Am
J Hum Genet. 2013 Aug 8;93(2):336-45. doi: 10.1016/j.ajhg.2013.06.007. Epub 2013
Jul 25. PubMed PMID: 23891469; PubMed Central PMCID: PMC3738827.

29: Wang HH, Hung CC, Hwang DY, Kuo MC, Chiu YW, Chang JM, Tsai JC, Hwang SJ,
Seifter JL, Chen HC. Hypokalemia, its contributing factors and renal outcomes in
patients with chronic kidney disease. PLoS One. 2013 Jul 2;8(7):e67140. doi:
10.1371/journal.pone.0067140. Print 2013. PubMed PMID: 23843989; PubMed Central
PMCID: PMC3699540.

30: Lin HY, Lee SC, Lin SF, Hsiao HH, Liu YC, Yang WC, Hwang DY, Hung CC, Chen
HC, Guh JY. Urinary neutrophil gelatinase-associated lipocalin levels predict
cisplatin-induced acute kidney injury better than albuminuria or urinary cystatin
C levels. Kaohsiung J Med Sci. 2013 Jun;29(6):304-11. doi:
10.1016/j.kjms.2012.10.004. Epub 2013 Jan 11. PubMed PMID: 23684135.

31: Chang JM, Hwang DY, Chen SC, Kuo MC, Hung CC, Hwang SJ, Tsai JC, Chen HC.
B7-1 expression regulates the hypoxia-driven cytoskeleton rearrangement in
glomerular podocytes. Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F127-36. doi:
10.1152/ajprenal.00108.2012. Epub 2012 Sep 26. PubMed PMID: 23019228.

32: Chang WC, Woon PY, Wei JC, Chang CM, Hsu YW, Guo YC, Hwang DY, Kochi Y, Yen
JH. A single-nucleotide polymorphism of CCR6 (rs3093024) is associated with
susceptibility to rheumatoid arthritis but not ankylosing spondylitis, in a
Taiwanese population. J Rheumatol. 2012 Aug;39(8):1765-6. doi:
10.3899/jrheum.120040. PubMed PMID: 22859539.

33: Huang JC, Kuo MC, Hwang SJ, Hwang DY, Chen HC. Vitamin D-mediated
hypercalcemia as the initial manifestation of pulmonary cryptococcosis in an
HIV-uninfected patient. Intern Med. 2012;51(13):1793-6. Epub 2012 Jul 1. PubMed
PMID: 22790148.

34: Tung SC, Hwang DY, Yang JW, Chen WJ, Lee CT. An unusual presentation of
Carney complex with diffuse primary pigmented nodular adrenocortical disease on
one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary
pigmented nodular adrenocortical disease on the other. Endocr J.
2012;59(9):823-30. Epub 2012 Jun 20. PubMed PMID: 22785148.

35: Tseng MH, Yang SS, Hsu YJ, Fang YW, Wu CJ, Tsai JD, Hwang DY, Lin SH.
Genotype, phenotype, and follow-up in Taiwanese patients with salt-losing
tubulopathy associated with SLC12A3 mutation. J Clin Endocrinol Metab. 2012
Aug;97(8):E1478-82. doi: 10.1210/jc.2012-1707. Epub 2012 Jun 7. PubMed PMID:
22679066.

36: Hwang DY, Hung CC, Riepe FG, Auchus RJ, Kulle AE, Holterhus PM, Chao MC, Kuo
MC, Hwang SJ, Chen HC. CYP17A1 intron mutation causing cryptic splicing in
17α-hydroxylase deficiency. PLoS One. 2011;6(9):e25492. doi:
10.1371/journal.pone.0025492. Epub 2011 Sep 26. PubMed PMID: 21966534; PubMed
Central PMCID: PMC3180445.

37: Chou YH, Woon PY, Chen WC, Hsu YW, Chang JM, Hwang DY, Chiu YC, Kuo HC, Chang
WP, Hou MF, Liu ME, Chang JG, Chang WC. A genetic polymorphism (rs17251221) in
the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in
calcium nephrolithiasis. PLoS One. 2011;6(9):e25227. doi:
10.1371/journal.pone.0025227. Epub 2011 Sep 22. PubMed PMID: 21966463; PubMed
Central PMCID: PMC3178627.

38: Wu PH, Hwang DY, Kuo MC, Hwang SJ, Chen HC. Pneumothorax in a female with
renal angiomyolipoma. Kaohsiung J Med Sci. 2011 Oct;27(10):469-72. doi:
10.1016/j.kjms.2011.06.008. Epub 2011 Jul 23. PubMed PMID: 21943821.

39: Lim LM, Tsai KB, Hwang DY, Kuo MC, Chiu YW, Chen HC. Anuric acute renal
failure after elective abortion. Intern Med. 2011;50(16):1715-8. Epub 2011 Aug
15. PubMed PMID: 21841331.

40: Liu WC, Hung CC, Chen SC, Lin MY, Chen LI, Hwang DY, Chang JM, Tsai JC, Chen
HC, Hwang SJ. The rs1014290 polymorphism of the SLC2A9 gene is associated with
type 2 diabetes mellitus in Han Chinese. Exp Diabetes Res. 2011;2011:527520. doi:
10.1155/2011/527520. Epub 2011 Apr 14. PubMed PMID: 21584282; PubMed Central
PMCID: PMC3092507.

41: Kuo HC, Yang KD, Juo SH, Liang CD, Chen WC, Wang YS, Lee CH, Hsi E, Yu HR,
Woon PY, Lin IC, Huang CF, Hwang DY, Lee CP, Lin LY, Chang WP, Chang WC. ITPKC
single nucleotide polymorphism associated with the Kawasaki disease in a
Taiwanese population. PLoS One. 2011 Apr 14;6(4):e17370. doi:
10.1371/journal.pone.0017370. PubMed PMID: 21533171; PubMed Central PMCID:
PMC3077380.

42: Chillambhi S, Turan S, Hwang DY, Chen HC, Jüppner H, Bastepe M. Deletion of
the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib
and biparental defects of GNAS methylation in cis. J Clin Endocrinol Metab. 2010
Aug;95(8):3993-4002. doi: 10.1210/jc.2009-2205. Epub 2010 May 5. PubMed PMID:
20444925; PubMed Central PMCID: PMC2913043.

43: Yeh IJ, Lin TJ, Hwang DY. Acute multiple organ failure with imidacloprid and
alcohol ingestion. Am J Emerg Med. 2010 Feb;28(2):255.e1-3. doi:
10.1016/j.ajem.2009.05.006. PubMed PMID: 20159407.

44: Li FC, Hwang DY, Hung CC, Chen HC. Pauci-immune lupus nephritis: a case
report. Kaohsiung J Med Sci. 2008 Oct;24(10):531-5. doi:
10.1016/S1607-551X(09)70012-9. PubMed PMID: 19181584.

45: Hwang DY, Ismail-Beigi F. Control of Glut1 promoter activity under basal
conditions and in response to hyperosmolarity: role of Sp1. Am J Physiol Cell
Physiol. 2006 Feb;290(2):C337-44. Epub 2005 Sep 14. PubMed PMID: 16162661.

46: Hossain MM, Hwang DY, Huang QQ, Sasaki Y, Jin JP. Developmentally regulated
expression of calponin isoforms and the effect of h2-calponin on cell
proliferation. Am J Physiol Cell Physiol. 2003 Jan;284(1):C156-67. Epub 2002 Sep
4. PubMed PMID: 12388067.

47: Hwang DY, Ismail-Beigi F. Glucose uptake and lactate production in cells
exposed to CoCl(2) and in cells overexpressing the Glut-1 glucose transporter.
Arch Biochem Biophys. 2002 Mar 15;399(2):206-11. PubMed PMID: 11888207.